KHIE operates two independent networks: a health information exchange (HIE) used to submit public health data and exchange clinical information in the KHIE community; and a health information service provider (HISP) used to send Direct secure messages between healthcare providers.

Healthcare providers can connect Direct-enabled EHR to the KHIE HISP via cross-enterprise, document-reliable interchange, also known as an XDR connection, to exchange summary-of-care records with other connected providers. A KHIE Direct secure messaging Web-based portal is available to healthcare providers who don't have EHR but need to exchange Direct messages. The KHIE HISP is DirectTrust-accredited and able to exchange Direct secure messages with more than 30 DirectTrust-accredited HISPs.

An HIE connection can be made through a virtual private network (VPN) or SOAP-based Web service connection.

KHIE conducts public health reporting with the CDC BioSense Registry, Kentucky Immunization Registry, Kentucky National Electronic Disease Surveillance System and Kentucky Cancer Registry. Immunization, syndromic surveillance and electronic laboratory reporting data can be submitted to KHIE through VPN or Web service connection. A Web service connection is required to submit cancer reports.

Providers also can connect to the KHIE HIE to exchange clinical information with other treating providers. Patient record queries return a summary-of-care record containing all clinical data submitted by KHIE participants. If the patient is a Medicaid participant, claims data will also be included in the summary of care record.

KHIE also supports Integrating the Healthcare Enterprise profiles for clinical document exchange. This means of exchange provides improved interoperability, care coordination and support for the meaningful use transitions of care objective.
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